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耳聾、常染色體隱性遺傳22抗體
  • 產(chǎn)品貨號(hào)：
    BN40283R
  • 中文名稱：
    耳聾、常染色體隱性遺傳22抗體
  • 英文名稱：
    Rabbit anti-OTOA Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40283R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat) 推薦應(yīng)用：WB,ELISA

  • BN40283R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱OTOA
中文名稱耳聾、常染色體隱性遺傳22抗體
別    名Cancer/testis antigen 108; CT108; Deafness, autosomal recessive 22; DFNB22; OTOA; OTOAN_HUMAN; Otoancorin.  
研究領(lǐng)域神經(jīng)生物學(xué)  細(xì)胞粘附分子  細(xì)胞外基質(zhì)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量122kDa
細(xì)胞定位細(xì)胞膜 細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human OTOA/DFNB22:231-330/1153 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Otoancorin, also known as OTOA, CT108 or DFNB22, is a 1,153 amino acid protein belonging to the stereocilin family. Expressed in the inner ear and restricted to the interface between the apical surface of sensory epithelia, otoancorin is suggested to act as an adhesion molecule. Otoancorin ensures the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in the gene encoding otoancorin leads to deafness autosomal recessive type 22 (DFNB22), which is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain or the area of the brain that receives sound information. Existing as three alternatively spliced isoforms, otoancorin is encoded by a gene located on human chromosome 16p12.2.

Function:
May act as an adhesion molecule.

Subcellular Location:
Apical cell membrane. Secreted > extracellular space > extracellular matrix. At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes.

DISEASE:
Defects in OTOA are the cause of deafness autosomal recessive type 22 (DFNB22) [MIM:607039]. DFNB22 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Similarity:
Belongs to the stereocilin family.

SWISS:
Q7RTW8

Gene ID:
146183

Database links:

Entrez Gene: 146183 Human

Entrez Gene: 246190 Mouse

Omim: 607038 Human

SwissProt: Q7RTW8 Human

SwissProt: Q8K561 Mouse

Unigene: 408336 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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