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代謝型谷氨酸受體1A抗體
  • 產(chǎn)品貨號(hào)：
    BN40345R
  • 中文名稱：
    代謝型谷氨酸受體1A抗體
  • 英文名稱：
    Rabbit anti-GRM1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40345R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Zebrafish(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN40345R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Zebrafish(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱GRM1
中文名稱代謝型谷氨酸受體1A抗體
別    名G protein coupled receptor family C group 1 member A; Glutamate receptor metabotropic 1 alpha; Glutamate receptor metabotropic 1; GPRC1A; GRM 1; GRM1 alpha; GRM1; GRM1A; Human metabotropic glutamate receptor 1 alpha mRNA complete cds; Metabotropic glutamate receptor 1 alpha; Metabotropic glutamate receptor 1; mGlu1; MGLUR1; MGLUR1A; mGluR1alpha; metabotropic glutamate receptor 1 isoform alpha; GRM1_HUMAN.  
研究領(lǐng)域細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞膜受體  G蛋白偶聯(lián)受體  新陳代謝  G蛋白信號(hào)  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Danio rerio)
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量130kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MGLUR1A/Metabotropic Glutamate Receptor 1a:151-250/1194 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Function:
Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.

Subunit:
Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP

Subcellular Location:
Cell Membrane; multi pass membrane protein.

Similarity:
Belongs to the G-protein coupled receptor 3 family.

SWISS:
Q13255

Gene ID:
2911

Database links:

Entrez Gene: 2911 Human

Entrez Gene: 14816 Mouse

Entrez Gene: 24414 Rat

Omim: 604473 Human

SwissProt: Q13255 Human

SwissProt: P97772 Mouse

SwissProt: P23385 Rat

Unigene: 32945 Human

Unigene: 391904 Mouse

Unigene: 482986 Mouse

Unigene: 87787 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.