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紅細(xì)胞分化相關(guān)基因蛋白抗體
  • 產(chǎn)品貨號：
    BN40360R
  • 中文名稱：
    紅細(xì)胞分化相關(guān)基因蛋白抗體
  • 英文名稱：
    Rabbit anti-Hemogen Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40360R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：nan(predicted:Human) 推薦應(yīng)用：WB,ELISA

  • BN40360R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：nan(predicted:Human) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱Hemogen
中文名稱紅細(xì)胞分化相關(guān)基因蛋白抗體
別    名EDAG; EDAG-1; Erythroid differentiation-associated gene protein; HEMGN; HEMGN_HUMAN; Hemogen; Hemopoietic gene protein; Negative differentiation regulator protein.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  細(xì)胞分化  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)(predicted: Human, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Hemogen/EDAG:51-150/484 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Hemogen is a 484 amino acid protein encoded by the human gene HEMGN. Hemogen is a nuclear protein that is expressed in hematopoietic precursor cells and can be detected in CD34+ and K-562 leukemia cell line. It is also expressed in bone marrow, testis, thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia. Hemogen is down-regulated during megakaryocytic differentiation of K-562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). It can be up-regulated in normal PBMCs by mitogens.

Function:
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in fetal liver, kidney and brain. Expressed in hematopoietic precursor cells (at protein level). Detected in CD34+ and K562 leukemia cell line (at protein level). Expressed in bone marrow, testis, thymus. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia.

SWISS:
Q9BXL5

Gene ID:
55363

Database links:

Entrez Gene: 55363 Human

Omim: 610715 Human

SwissProt: Q9BXL5 Human

Unigene: 176626 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.