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生長(zhǎng)抑制因子基因1抗體
  • 產(chǎn)品貨號(hào)：
    BN40399R
  • 中文名稱：
    生長(zhǎng)抑制因子基因1抗體
  • 英文名稱：
    Rabbit anti-ING1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40399R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat) 推薦應(yīng)用：WB,ELISA

  • BN40399R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱ING1
中文名稱生長(zhǎng)抑制因子基因1抗體
別    名ING1_HUMAN; Inhibitor of growth protein 1; inhibitor of growth gene 1; Growth inhibitor ING 1; Growth inhibitor ING1; Growth inhibitory protein ING 1; Growth inhibitory protein ING1; Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds; ING 1; Inhibitor of growth 1; Inhibitor of growth family member 1; Inhibitor of growth protein 1; p24ING1c; p33 ING1; p33ING1; p33ING1b; p47ING1a; Tumor suppressor ING 1; Tumor suppressor ING1.  
研究領(lǐng)域腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  細(xì)胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量46kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human inhibitor of growth gene 1:301-422/422 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].

Function:
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Subcellular Location:
Nucleus.

Tissue Specificity:
Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.

DISEASE:
Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.

Similarity:
Belongs to the ING family.
Contains 1 PHD-type zinc finger.

SWISS:
Q9UK53

Gene ID:
3621

Database links:

Entrez Gene: 3621 Human

Entrez Gene: 26356 Mouse

Entrez Gene: 306626 Rat

GenBank: NP_937862 Human

Omim: 601566 Human

SwissProt: Q9UK53 Human

SwissProt: Q9QXV3 Mouse

Unigene: 46700 Human

Unigene: 508725 Human

Unigene: 25709 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

腫瘤的發(fā)生是一個(gè)多基因參與,多步驟發(fā)生的復(fù)雜過程，抑癌基因的功能失活與癌基因的激活為其主要原因之一。 ING1基因是近期發(fā)現(xiàn)的抑癌基因，研究發(fā)現(xiàn)，它的過表達(dá)可抑制細(xì)胞生長(zhǎng)、增殖,促進(jìn)細(xì)胞凋亡，它的低表達(dá)與腫瘤的發(fā)生、發(fā)展有關(guān)。ING1正常時(shí)定位于胞核，發(fā)揮其誘導(dǎo)凋亡和調(diào)控細(xì)胞周期的作用，當(dāng)其易位于胞質(zhì)時(shí)上述作用逐步減弱或消失，在腫瘤發(fā)生時(shí)，多位于胞漿。