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胚胎干細(xì)胞相關(guān)轉(zhuǎn)錄因子1抗體
  • 產(chǎn)品貨號：
    BN40431R
  • 中文名稱：
    胚胎干細(xì)胞相關(guān)轉(zhuǎn)錄因子1抗體
  • 英文名稱：
    Rabbit anti-Ecat1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價(jià)

    備注

  • BN40431R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40431R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱Ecat1
中文名稱胚胎干細(xì)胞相關(guān)轉(zhuǎn)錄因子1抗體
別    名C6orf221; Chromosome 6 open reading frame 221; ES cell-associated transcript 1 protein; HYDM2; KHD3L_HUMAN; KHDC3-like protein; KHDC3L.  
研究領(lǐng)域細(xì)胞生物  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量24kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Ecat1:1-100/217 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹ECAT1 (ES cell-associated transcript 1 protein) is a 217 amino acid protein that belongs to the KHDC1 family. The ECAT1 protein contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA. Expression of ECAT1 appears to be maximal in germinal vesicle oocytes, it tails off through metaphase II oocytes and is undetectable following the completion of the oocyte to embryo transition. Specifically expressed in the oocytes, recent studies suggest that ECAT1 may function as a regulator of genomic imprinting in the oocyte. Defects in ECAT1 are the cause of hydatidiform mole recurrent type 2 (HYDM2), a disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. HYDM2 leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi.

Tissue Specificity:
Expression appears to be maximal in germinal vesicle oocytes, it tails off through metaphase II oocytes and is undetectable following the completion of the oocyte to embryo transition.

DISEASE:
Defects in KHDC3L are the cause of hydatidiform mole recurrent type 2 (HYDM2) [MIM:614293]. A disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi.

Similarity:
Belongs to the KHDC1 family. Contains 1 KH domain.

SWISS:
Q587J8

Gene ID:
154288

Database links:

Entrez Gene: 154288 Human

Omim: 611687 Human

SwissProt: Q587J8 Human

Unigene: 128326 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.