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驅(qū)動(dòng)蛋白家族成員13A抗體
  • 產(chǎn)品貨號(hào)：
    BN40481R
  • 中文名稱：
    驅(qū)動(dòng)蛋白家族成員13A抗體
  • 英文名稱：
    Rabbit anti-KIF13A Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40481R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40481R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱KIF13A
中文名稱驅(qū)動(dòng)蛋白家族成員13A抗體
別    名bA500C11.2; FLJ27232; KI13A_HUMAN; KIF 13A; Kif13a; Kinesin family member 13A; Kinesin like protein KIF13A; Kinesin like protein RBKIN; Kinesin-like protein KIF13A; Kinesin-like protein RBKIN; RBKIN.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量202kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human KIF13A:1501-1600/1805 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Function:
Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.

Subcellular Location:
Cytoplasm > cytoskeleton > centrosome. Midbody. Endosome membrane. Golgi apparatus membrane. Recruited to the midbody during cytokinesis.

Tissue Specificity:
Widely expressed, with highest levels in heart, brain and skeletal muscle.

Similarity:
Belongs to the kinesin-like protein family.
Contains 1 FHA domain.
Contains 1 kinesin-motor domain.

SWISS:
Q9H1H9

Gene ID:
63971

Database links:

Entrez Gene: 63971 Human

Omim: 605433 Human

SwissProt: Q9H1H9 Human

Unigene: 94499 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.