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SKOR2蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN40503R
  • 中文名稱：
    SKOR2蛋白抗體
  • 英文名稱：
    Rabbit anti-SKOR2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN40503R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Cow,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40503R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Cow,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱SKOR2
中文名稱SKOR2蛋白抗體
別    名CORL2; Functional smad suppressing element 18; Functional Smad-suppressing element on chromosome 18; Fussel-18; FUSSEL18; Ladybird homeobox corepressor 1-like protein; LBX1 corepressor 1-like protein; SKI family transcriptional corepressor 2; SKOR2; SKOR2_HUMAN.  
研究領(lǐng)域神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Dog, Cow, Sheep, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量104kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SKOR2:871-970/1001 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The sloan kettering virus (Ski) family of nuclear oncoproteins act as transcriptional regulators of TGF-β by interacting directly with SMAD proteins. Fussel-18 (functional Smad-suppressing element on chromosome 18), also known as SKOR2 (Ski family transcriptional corepressor 2), LBX1 corepressor 1-like protein, ladybird homeobox corepressor 1-like protein or CORL2, is a 1,001 amino acid protein that belongs to the Ski family. Localizing to nucleus as well as cytoplasm, Fussel-18 is expressed in cerebellum, spinal cord and testis. Fussel-18 acts as an antagonist to TGF-β in the nervous system, possibly by functioning as a transcriptional repressor of SMAD2 and SMAD3. Existing as two alternatively spliced isoforms, the gene encoding Fussel-18 maps to human chromosome 18q21.1 and mouse chromosome 18 E3.

Function:
Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Expressed in cerebellum, spinal cord and testis. Isoform 2 is present in cerebellum (at protein level).

Similarity:
Belongs to the SKI family.

SWISS:
Q2VWA4

Gene ID:
652991

Database links:

Entrez Gene: 652991 Human

SwissProt: Q2VWA4 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.