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磷酸化絲氨酸/蘇氨酸蛋白激酶MAK抗體
  • 產(chǎn)品貨號(hào)：
    BN40530R
  • 中文名稱：
    磷酸化絲氨酸/蘇氨酸蛋白激酶MAK抗體
  • 英文名稱：
    Rabbit anti-phospho-MAK (Tyr159) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40530R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱phospho-MAK (Tyr159)
中文名稱磷酸化絲氨酸/蘇氨酸蛋白激酶MAK抗體
別    名MAK (phospho Tyr159); MAK (phospho Y159); dJ417M14.2; Mak; MAK_HUMAN; Male germ cell associated kinase; Male germ cell-associated kinase; OTTHUMP00000016025; Rck; Serine/threonine protein kinase MAK; Serine/threonine-protein kinase MAK.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域細(xì)胞生物  發(fā)育生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量71kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human MAK around the phosphorylation site of Tyr159:TD(p-Y)VS 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Function:
Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis.
May play a role in chromosomal stability in prostate cancer cells.

Subcellular Location:
Nucleus. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Midbody. Cell projection > cilium > photoreceptor outer segment. Photoreceptor inner segment. Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase.

Tissue Specificity:
Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors.

Post-translational modifications:
Autophosphorylated. Phosphorylated on serine and threonine residues.

DISEASE:
Defects in MAK are the cause of retinitis pigmentosa type 62 (RP62) [MIM:614181]. RP62 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Similarity:
Belongs to the protein kinase superfamily.
CMGC Ser/Thr protein kinase family.
CDC2/CDKX subfamily. Contains 1 protein kinase domain.

SWISS:
P20794

Gene ID:
4117

Database links:

Entrez Gene: 4117 Human

Entrez Gene: 17152 Mouse

Entrez Gene: 25677 Rat

Omim: 154235 Human

SwissProt: P20794 Human

SwissProt: Q04859 Mouse

SwissProt: P20793 Rat

Unigene: 446125 Human

Unigene: 8149 Mouse

Unigene: 9670 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications