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蛋白酶體26S亞基ATP酶3抗體

產(chǎn)品貨號：

BN40561R
中文名稱：

蛋白酶體26S亞基ATP酶3抗體
英文名稱：

Rabbit anti-PSMC3 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN40561R-100ul

100ul

￥2360.00

交叉反應(yīng)：Human,Mouse(predicted:Dog,Cow,Horse,Xenopus laevis) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40561R-200ul

200ul

￥3490.00

交叉反應(yīng)：Human,Mouse(predicted:Dog,Cow,Horse,Xenopus laevis) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱	PSMC3
中文名稱	蛋白酶體26S亞基ATP酶3抗體
別名	26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; Human immunodeficiency virus tat transactivator binding protein 1; MGC8487; Proteasome (prosome macropain) 26S subunit ATPase 3; Proteasome 26S ATPase subunit 3; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; PRS6A_HUMAN; PSMC 3; PSMC3; Tat binding protein 1; TAT-binding protein 1; TBP-1; TBP1.
研究領(lǐng)域	細(xì)胞生物結(jié)合蛋白泛素
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Human, Mouse, (predicted: Dog, Cow, Horse, Xenopus laevis)
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	49kDa
細(xì)胞定位	細(xì)胞核細(xì)胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human PSMC3:212-220/439
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008] Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation. Subcellular Location: Cytoplasm. Nucleus. Post-translational modifications: Sumoylated by UBE2I in response to MEKK1-mediated stimuli. Similarity: Belongs to the AAA ATPase family. SWISS: P17980 Gene ID: 5702 Database links: Entrez Gene: 5702 Human Entrez Gene: 19182 Mouse Entrez Gene: 29677 Rat Entrez Gene: 379370 Xenopus laevis Omim: 186852 Human SwissProt: P17980 Human SwissProt: O88685 Mouse SwissProt: Q63569 Rat SwissProt: O42586 Xenopus laevis Unigene: 250758 Human Unigene: 289832 Mouse Unigene: 11173 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.