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產(chǎn)品規(guī)格
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BN40634R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse(predicted:Rat,Dog,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,ELISA
BN40634R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse(predicted:Rat,Dog,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,ELISA
產(chǎn)品描述
| 英文名稱 | B7H4 |
| 中文名稱 | B7-H4抗體 |
| 別 名 | B7-H4; B7h4; B7S1; B7x; BC032925; Immune costimulatory protein B7H4; MGC41287; PRO1291; T cell costimulatory molecule B7x; V set domain-containing T cell activation inhibitor 1; VCTN1; VTCN1_HUMAN. |
| 研究領域 | 腫瘤 免疫學 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, (predicted: Rat, Dog, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human B7H4:101-200/282 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | B7-H4 protein is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell responses. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues. Function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Subcellular Location: cell membrane; Single-pass type I membrane protein (Potential). Note=Expressed at the cell surface. A soluble form has also been detected. Tissue Specificity: Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. Post-translational modifications: N-glycosylated. Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 2 Ig-like V-type (immunoglobulin-like) domains. SWISS: Q7Z7D3 Gene ID: 79679 Database links: Entrez Gene: 79679 Human Entrez Gene: 242122 Mouse Omim: 608162 Human SwissProt: Q7Z7D3 Human SwissProt: Q7TSP5 Mouse Unigene: 546434 Human Unigene: 137467 Mouse Unigene: 160956 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. B7-H4(B7 Homolog 4)是B7家族中的新成員,它能通過抑制T細胞的增殖、細胞因子的產(chǎn)生和細胞周期的進程來負性調(diào)控T細胞的免疫應答,其大量表達B7-H4還可以促進上皮細胞的惡性轉(zhuǎn)化,保護表皮細胞免于失巢凋亡,在腫瘤的發(fā)生,進展和轉(zhuǎn)歸中發(fā)揮重要作用. 目前對B7-H4信號通路的進一步的研究必將為自身免疫性疾病、病毒感染性疾病和器官移植后排斥反應中T細胞介導的免疫應答調(diào)控提供了新的途徑,同時也為腫瘤的診斷、治療提供嶄新的前景。 |
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