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首頁>>免疫學>>一抗>>CD24抗體
CD24抗體
  • 產(chǎn)品貨號：
    BN40799R
  • 中文名稱：
    CD24抗體
  • 英文名稱：
    Rabbit anti-CD24 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40799R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN40799R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱CD24
中文名稱CD24抗體
別    名CD 24; CD24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD24 antigen; CD24 molecule; CD24_HUMAN; CD24A; GPI linked surface mucin; Heat stable antigen; HSA; Nectadrin; Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; Cd24; Cd24a; Ly-52.  
研究領域腫瘤  細胞生物  免疫學  神經(jīng)生物學  信號轉(zhuǎn)導  干細胞  細胞粘附分子  糖蛋白  細胞類型標志物  t-淋巴細胞  b-淋巴細胞  骨髓細胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat, 
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量3/8kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CD24 :35-80/80 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹CD24 (also known as heat stable antigen) is a phosphatidylinositol linked cell surface glycoprotein with a polypeptide core of 30 amino acids and high carbohydrate content. The apparent molecular mass of the two forms of CD24 purified from a mouse lymphoma cell line appear to be in the range of 40-60 and 23-30 kDa. CD24 is expressed at all stages of B cell development and on most thymocytes. The absence of expression from mature T cells is closely associated with their maturation from CD4+ CD8+ CD24+ thymocytes to either CD4+ CD8- CD24- or CD4- CD8+ CD24- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes. Its ligand is P selectin (CD62P). CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes. CD24 is also a positive marker of pancreatic cancer.

Function:
Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.

DISEASE:
Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface.

Similarity:
Belongs to the CD24 family.

SWISS:
P25063

Gene ID:
100133941

Database links:

Entrez Gene: 100133941 Human

Entrez Gene: 12484 Mouse

Entrez Gene: 25145 Rat

Omim: 600074 Human

SwissProt: P25063 Human

SwissProt: P24807 Mouse

SwissProt: Q07490 Rat

Unigene: 644105 Human

Unigene: 721443 Human

Unigene: 29742 Mouse

Unigene: 6007 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)干細胞標志物 腫瘤標志物 CD24是一種低分子質(zhì)量高度糖基化的黏附分子, 主要表達在造血系統(tǒng). 最近研究表明, 在造血系統(tǒng)腫瘤和一些器官的實體瘤表面可見CD24高表達。近幾年很多學者認為：CD24在前列腺癌、非小細胞肺癌、鼻咽癌、原發(fā)性肝細胞癌、膽管細胞癌、麥克爾細胞癌、神經(jīng)源性腫瘤、胰腺癌、胃癌、結(jié)腸癌、腎細胞癌、B細胞