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轉(zhuǎn)化生長因子β調(diào)節(jié)蛋白1抗體
  • 產(chǎn)品貨號：
    BN41010R
  • 中文名稱：
    轉(zhuǎn)化生長因子β調(diào)節(jié)蛋白1抗體
  • 英文名稱：
    Rabbit anti-TBRG1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41010R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41010R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱TBRG1
中文名稱轉(zhuǎn)化生長因子β調(diào)節(jié)蛋白1抗體
別    名NIAM; Nuclear interactor of ARF and Mdm2; Transforming growth factor beta regulator 1; TBRG1; TBRG-1; TBRG 1; Transforming growth factor beta regulator 1.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  細(xì)胞周期蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TBRG1:28-130/411 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Acts as a growth inhibitor. Can activate TP53/p53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. There are two isoforms.

Function:
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.

Subunit:
Interacts with CDKN2A and MDM2.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma.

Post-translational modifications:
Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.

Similarity:
Belongs to the TBRG1 family.
Contains 1 FYR C-terminal domain.
Contains 1 FYR N-terminal domain.

SWISS:
Q3YBR2

Gene ID:
84897

Database links:

Entrez Gene: 84897 Human

Entrez Gene: 21376 Mouse

Entrez Gene: 300521 Rat

Omim: 610614 Human

SwissProt: Q3YBR2 Human

SwissProt: Q3UB74 Mouse

SwissProt: Q5PQK8 Rat

Unigene: 436410 Human

Unigene: 28689 Mouse

Unigene: 129282 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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