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磷酸吡哆醇氧化酶抗體
  • 產(chǎn)品貨號：
    BN41041R
  • 中文名稱：
    磷酸吡哆醇氧化酶抗體
  • 英文名稱：
    Rabbit anti-PNPO Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41041R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat(predicted:Human,Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41041R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat(predicted:Human,Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱PNPO
中文名稱磷酸吡哆醇氧化酶抗體
別    名PDXPO; PNPO; PNPO_HUMAN; Pyridoxal 5' phosphate synthase; pyridoxamine 5' phosphate oxidase; Pyridoxamine phosphate oxidase; Pyridoxamine-phosphate oxidase; pyridoxine 5' phosphate oxidase; Pyridoxine-5''-phosphate oxidase; EC 1.4.3.5; FLJ10535.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Rat,  (predicted: Human, Mouse, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PNPO:41-140/261 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

Function:
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

Subunit:
Homodimer.

DISEASE:
Defects in PNPO are the cause of pyridoxine-5'-phosphate oxidase deficiency (PNPO deficiency) [MIM:610090]; also known as PNPO-related neonatal epileptic encephalopathy. The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine.

Similarity:
Belongs to the pyridoxamine 5'-phosphate oxidase family.

SWISS:
Q9NVS9

Gene ID:
55163

Database links:

Entrez Gene: 55163 Human

Entrez Gene: 103711 Mouse

Entrez Gene: 64533 Rat

Omim: 603287 Human

SwissProt: Q9NVS9 Human

SwissProt: Q91XF0 Mouse

SwissProt: O88794 Rat

Unigene: 631742 Human

Unigene: 254704 Mouse

Unigene: 158883 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PNPO是維生素B6(VB6)代謝的關(guān)鍵酶，參與催化氨基酸代謝的各種反應(yīng)和其它多種代謝過程。