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肝癌上調(diào)蛋白抗體
  • 產(chǎn)品貨號：
    BN41166R
  • 中文名稱：
    肝癌上調(diào)蛋白抗體
  • 英文名稱：
    Rabbit anti-HURP Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41166R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41166R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱HURP
中文名稱肝癌上調(diào)蛋白抗體
別    名DAP-5; DAP5; Discs large homolog 7; Disks large associated protein 5; Disks large associated protein DLG7; Disks large-associated protein 5; Disks large-associated protein DLG7; DLG 1; DLG 7; DLG1; DLG7; DLGAP5; DLGP5_HUMAN; Drosophila discs large 1 tumor suppressor like; Hepatoma up regulated protein; Hepatoma up-regulated protein; Hepatoma upregulated protein; HURP.  
研究領(lǐng)域腫瘤  免疫學(xué)  細(xì)胞周期蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量93kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HURP:51-150/846 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

Function:
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

Subunit:
Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1.

Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.

Tissue Specificity:
Expressed at low levels in normal resting liver. Up-regulated in regenerating liver after partial hepatectomy.

Post-translational modifications:
Ubiquitinated, leading to its degradation.
Phosphorylated upon DNA damage, probably by ATM or ATR. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.

Similarity:
Belongs to the SAPAP family.

SWISS:
Q15398

Gene ID:
9787

Database links:

Entrez Gene: 9787 Human

SwissProt: Q15398 Human

Unigene: 77695 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
















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