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淋巴細胞性白血病相關(guān)序列1抗體
  • 產(chǎn)品貨號：
    BN41316R
  • 中文名稱：
    淋巴細胞性白血病相關(guān)序列1抗體
  • 英文名稱：
    Rabbit anti-LYL1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41316R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Pig,Cow) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

  • BN41316R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Pig,Cow) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱LYL1
中文名稱淋巴細胞性白血病相關(guān)序列1抗體
別    名Lyl1; Lymphoblastic leukemia derived sequence 1; Protein lyl 1.  
研究領(lǐng)域腫瘤  細胞生物  免疫學(xué)  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, Pig, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量31kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human LYL1:151-250/280 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The Lyl1 gene encodes a basic helix–loop–helix transcription factor involved in T-cell acute lymphoblastic leukemia. The expression of Lyl1 is at higher levels in the majority of cases of acute myeloblastic leukemia (AML) or myelodysplastic syndrome when compared to normal bone marrow. Lyl1 is highly expressed in most AML cell lines.Lyl-1, TAL1 and TAL2 are part of a family of basic helix-loop-helix (bHLH) proteins implicated in T cell acute leukemia. TAL1, also designated SCL, is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. TAL2 is a protein involved in T cell acute lymphoblastic leukemia through a chromosomal translocation involving TAL2 and T cell receptor ∫ chain genes. TAL2 includes a helix-loop-helix protein dimerization and DNA-binding domain that is homologous to TAL1 and Lyl-1 proto-oncogenes. Lyl-1 (lymphoblastic leukemia-derived sequence 1) is a nuclear protein. Endogenous Lyl-1 exists in complex with E2? proteins. Lyl-1 and E2? protein can form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Lyl-1 is involved in a chromosomal aberration which causes a form of T cell acute lymphoblastic leukemia (T-ALL).

Function:
Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular Location:
Nucleus (Potential).

DISEASE:
Note=A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

SWISS:
P12980

Gene ID:
4066

Database links:

Entrez Gene: 4066 Human

Entrez Gene: 17095 Mouse

Entrez Gene: 304663 Rat

Omim: 151440 Human

SwissProt: P12980 Human

SwissProt: P27792 Mouse

SwissProt: Q66HH3 Rat

Unigene: 46446 Human

Unigene: 728534 Human

Unigene: 4925 Mouse

Unigene: 17352 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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