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AKIRIN1蛋白抗體
  • 產(chǎn)品貨號：
    BN41361R
  • 中文名稱：
    AKIRIN1蛋白抗體
  • 英文名稱：
    Rabbit anti-AKIRIN1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41361R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat(predicted:Human,Mouse,Dog,Horse,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41361R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat(predicted:Human,Mouse,Dog,Horse,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱AKIRIN1
中文名稱AKIRIN1蛋白抗體
別    名AKIRIN 1; C1orf108; FLJ12666; OTTHUMP00000008669; RP11-781D11.2; STRF2; AKIR1_HUMAN.  
研究領(lǐng)域細胞生物  免疫學(xué)  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Rat,  (predicted: Human, Mouse, Dog, Horse, Sheep, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human AKIRIN1:101-192/192 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways.

Subcellular Location:
Nuclear

Tissue Specificity:
Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes.

Similarity:
Belongs to the akirin family.

SWISS:
Q9H9L7

Gene ID:
79647

Database links:

Entrez Gene: 79647 Human

Entrez Gene: 68050 Mouse

Entrez Gene: 595134 Rat

Omim: 615164 Human

SwissProt: Q9H9L7 Human

SwissProt: Q99LF1 Mouse

Unigene: 293563 Human

Unigene: 27903 Mouse

Unigene: 390996 Mouse

Unigene: 486258 Mouse

Unigene: 3674 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications