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低密度脂蛋白受體的誘導(dǎo)降解蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41398R
  • 中文名稱：
    低密度脂蛋白受體的誘導(dǎo)降解蛋白抗體
  • 英文名稱：
    Rabbit anti-MYLIP Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

    產(chǎn)品規(guī)格

    售價(jià)

    備注

  • BN41398R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,ELISA

  • BN41398R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱MYLIP
中文名稱低密度脂蛋白受體的誘導(dǎo)降解蛋白抗體
別    名BZF1; E3 ubiquitin protein ligase MYLIP; E3 ubiquitin-protein ligase MYLIP; Idol; Inducible degrader of the LDL-receptor; Idol; MIR; MYLIP; MYLIP_HUMAN; Myosin regulatory light chain interacting protein.  
研究領(lǐng)域心血管  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  細(xì)胞骨架  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MYLIP:51-150/445 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Subunit:
Interacts with myosin regulatory light chain (MRLC) and TMEM4.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Autoubiquitinated.

Similarity:
Contains 1 FERM domain.
Contains 1 RING-type zinc finger.

SWISS:
Q8WY64

Gene ID:
29116

Database links:

Entrez Gene: 29116 Human

Entrez Gene: 218203 Mouse

Omim: 610082 Human

SwissProt: Q8WY64 Human

SwissProt: Q8BM54 Mouse

Unigene: 484738 Human

Unigene: 212855 Mouse

Unigene: 481228 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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