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堿性成纖維細(xì)胞生長(zhǎng)因子/FGF2抗體
  • 產(chǎn)品貨號(hào)：
    BN41513R
  • 中文名稱：
    堿性成纖維細(xì)胞生長(zhǎng)因子/FGF2抗體
  • 英文名稱：
    Rabbit anti-bFGF Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41513R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41513R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41513R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱bFGF
中文名稱堿性成纖維細(xì)胞生長(zhǎng)因子/FGF2抗體
別    名Basic fibroblast growth factor; FGF basic; FGF-basic; BFGF; FGF-2; FGF B; FGF2; FGF2 basic; FGFB; Fibroblast growth factor 2 (basic); HBGF 2; HBGF-2; HBGF2; HBGH 2; HBGH2; Heparin binding growth factor 2 precursor; Prostatropin; FGF2_HUMAN.  
研究領(lǐng)域腫瘤  心血管  細(xì)胞生物  免疫學(xué)  生長(zhǎng)因子和激素  細(xì)胞因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量18kDa
細(xì)胞定位細(xì)胞核 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human bFGF:143-250/288 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008].

Function:
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

Subunit:
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2.

Subcellular Location:
Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.

Tissue Specificity:
Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.

Post-translational modifications:
Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.

Similarity:
Belongs to the heparin-binding growth factors family.

SWISS:
P09038

Gene ID:
2247

Database links:

Entrez Gene: 2247 Human

Entrez Gene: 14173 Mouse

Entrez Gene: 54250 Rat

Omim: 134920 Human

SwissProt: P09038 Human

SwissProt: P15655 Mouse

SwissProt: P13109 Rat

Unigene: 284244 Human

Unigene: 473689 Mouse

Unigene: 31808 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生長(zhǎng)因子和激素（ Growth Factor and Hormones）

(b-FGF)主要分布于垂體、腦和神經(jīng)組織及視網(wǎng)膜、腎上腺、胎盤等，尤以垂體含量最高。
FGF2(basic fibroblast growth factor)堿性成纖維細(xì)胞生長(zhǎng)因子是由內(nèi)皮細(xì)胞及平滑肌細(xì)胞合成并對(duì)合成細(xì)胞有促分裂效應(yīng)的多肽分子,具有強(qiáng)烈的血管生成作用，參與血管生成、組織修復(fù)、神經(jīng)系統(tǒng)的發(fā)育等 。FGF2在體外，能刺激細(xì)胞增殖，細(xì)胞遷移，誘導(dǎo)纖溶酶原激活物及膠原酶活性。是能與肝素結(jié)合的促分裂劑。
FGF家族參與一系列重要的生理功能：胚胎發(fā)育、細(xì)胞生長(zhǎng)、組織的修復(fù)、器官的形成、腫瘤的浸潤(rùn)和生長(zhǎng)等。