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脂肪細胞增強結(jié)合蛋白1
  • 產(chǎn)品貨號：
    BN41527R
  • 中文名稱：
    脂肪細胞增強結(jié)合蛋白1
  • 英文名稱：
    Rabbit anti-AEBP1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41527R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41527R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41527R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱AEBP1
中文名稱脂肪細胞增強結(jié)合蛋白1
別    名AE binding protein 1; ACLP; Adipocyte enhancer binding protein 1; AEBP 1; AEBP1; Aortic carboxypeptidase like protein ACLP;Aortic carboxypeptidase like protein; FLJ33612; AEBP1_HUMAN; Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein.  
研究領(lǐng)域免疫學(xué)  染色質(zhì)和核信號  轉(zhuǎn)錄調(diào)節(jié)因子  結(jié)合蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量128/80kDa
細胞定位細胞核 細胞漿 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human AEBP1:101-200/728 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013].

Function:
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

Subunit:
Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. May interact with calmodulin. Binds to DNA in vitro.

Subcellular Location:
Isoform 1: Secreted.
Isoform 2: Cytoplasm (Probable). Nucleus (Probable).

Tissue Specificity:
Expressed in osteoblast and visceral fat.

Post-translational modifications:
Phosphorylated by MAPK1 in vitro.

Similarity:
Belongs to the peptidase M14 family.
Contains 1 F5/8 type C domain.

SWISS:
Q14113

Gene ID:
165

Database links:

Entrez Gene: 165 Human

Omim: 602981 Human

SwissProt: Q14113 Human

Unigene: 439463 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.