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血管內(nèi)皮細胞粘附分子抗體
  • 產(chǎn)品貨號：
    BN41598R
  • 中文名稱：
    血管內(nèi)皮細胞粘附分子抗體
  • 英文名稱：
    Rabbit anti-VCAM1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41598R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Sheep,Rabbit,Mouse,Human(predicted:Pig,Rat) 推薦應(yīng)用：WB,ELISA

  • BN41598R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Sheep,Rabbit,Mouse,Human(predicted:Pig,Rat) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱VCAM1
中文名稱血管內(nèi)皮細胞粘附分子抗體
別    名CD 106; CD106; CD106 Antigen; DKFZp779G2333; INCAM 100; MGC99561; Vascular Cell Adhesion Molecule 1; Vascular cell adhesion protein 1; VCAM 1; VCAM-1; INCAM-100; V-CAM 1; VCAM1_HUMAN.  


研究領(lǐng)域腫瘤  心血管  細胞生物  細胞粘附分子  內(nèi)皮細胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rabbit, Sheep,  (predicted: Rat, Pig, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量81kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human VCAM-1:651-739/739 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹VCAM1 is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells.

Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Subunit:
Binds to ECMV-D capsid proteins and acts as a receptor for this virus.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.

Similarity:
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
P19320

Gene ID:
7412

Database links:

Entrez Gene: 7412 Human

Entrez Gene: 22329 Mouse

Entrez Gene: 25361 Rat

GenBank: NP_001069.1 Human

GenBank: NP_001186763.1 Human

Omim: 192225 Human

SwissProt: P19320 Human

SwissProt: P29533 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細胞粘附蛋白（Call Adhesion Protein）
CD106是一種膜相關(guān)蛋白，分布于血管內(nèi)皮及其周圍的淋巴細胞、單核細胞、嗜酸性粒細胞和中性粒細胞。Anti-VCAM-1主要用于各種組織中血管內(nèi)皮的檢測。
















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