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細(xì)胞角蛋白18單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN41997M
  • 中文名稱(chēng)：
    細(xì)胞角蛋白18單克隆抗體
  • 英文名稱(chēng)：
    Mouse anti-CK18 Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

    產(chǎn)品規(guī)格

    售價(jià)

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  • BN41997M-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human(predicted:Mouse) 推薦應(yīng)用：WB,ICC

  • BN41997M-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse) 推薦應(yīng)用：WB,ICC

  • BN41997M-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse) 推薦應(yīng)用：WB,ICC

產(chǎn)品描述

英文名稱(chēng)CK18
中文名稱(chēng)細(xì)胞角蛋白18單克隆抗體
別    名Cell proliferation inducing gene 46 protein; Cell proliferation inducing protein 46; CK 18; CK18; CYK18; Cytokeratin 18; Cytokeratin endo B; Cytokeratin18; Keratin 18; Keratin D; Keratin type I cytoskeletal 18; Kerd; KRT18.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來(lái)源Mouse
克隆類(lèi)型Monoclonal
克 隆 號(hào)4H7
交叉反應(yīng)Human,  (predicted: Mouse, )
產(chǎn)品應(yīng)用WB=1:500-1000 ICC=1:100 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量48kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CK18: 
亞    型IgG
純化方法affinity purified by Protein G
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].

Function:
When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Post-translational modifications:
Phosphorylation increases by IL-6.
Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-231 by either caspase-3, caspas-6 or caspase-7.
O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residue.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P05783

Gene ID:
3875

Database links:

Entrez Gene: 506480 Cow

Entrez Gene: 3875 Human

Entrez Gene: 16668 Mouse

Entrez Gene: 294853 Rat

Omim: 148070 Human

SwissProt: P05783 Human

SwissProt: P05784 Mouse

SwissProt: Q5BJY9 Rat

Unigene: 406013 Human

Unigene: 22479 Mouse

Unigene: 103924 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

結(jié)構(gòu)蛋白（Structural Proteins）
常用于腫瘤細(xì)胞的分化、增殖及轉(zhuǎn)移方面的研究。