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子宮珠蛋白重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42158R
  • 中文名稱：
    子宮珠蛋白重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-SCGB1A1/Uteroglobin Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN42158R-50ul

    50ul

    ￥2020.00

    交叉反應：Human(predicted:Mouse,Rat) 推薦應用：WB,ICC

  • BN42158R-100ul

    100ul

    ￥3240.00

    交叉反應：Human(predicted:Mouse,Rat) 推薦應用：WB,ICC

產(chǎn)品描述

英文名稱Uteroglobin
中文名稱子宮珠蛋白重組兔單克隆抗體
別    名blastokinin; CC10; CC16; CCPBP; CCSP; Clara cell phospholipid binding protein; Clara cell phospholipid-binding protein; clara cell secretory protein; Clara cell specific 10 kD protein; Clara Cells 10 kDa Secretory Protein; OTTHUMP00000236107; Secretoglobin family 1A member 1; Secretoglobin, family 1A, member 1 (uteroglobin); UG; UGB; UP-1; UP1; Urinary Protein 1; Urine Protein 1; UTER_HUMAN; SCGB1A1; Utg.  
研究領(lǐng)域細胞生物  免疫學  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號7G5
交叉反應Human,  (predicted: Mouse, Rat, )
產(chǎn)品應用WB=1:500-1000 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量8kDa
細胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human Uteroglobin: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as, a number of other immunomodulatory features including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion.

Function:
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

Subunit:
Homodimer; antiparallel disulfide-linked.

Subcellular Location:
Secreted.

Tissue Specificity:
Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Similarity:
Belongs to the secretoglobin family.

SWISS:
P11684

Gene ID:
7356

Database links:

Entrez Gene: 7356 Human

Entrez Gene: 22287 Mouse

Entrez Gene: 25575 Rat

Omim: 192020 Human

SwissProt: P11684 Human

SwissProt: Q06318 Mouse

SwissProt: P17559 Rat

Unigene: 523732 Human

Unigene: 2258 Mouse

Unigene: 2206 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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