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凝溶膠蛋白重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42159R
  • 中文名稱：
    凝溶膠蛋白重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-Gelsolin Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN42159R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human,Mouse 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

  • BN42159R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human,Mouse 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱Gelsolin
中文名稱凝溶膠蛋白重組兔單克隆抗體
別    名Actin depolymerizing factor; ADF; AGEL; Amyloidosis Finnish type; Brevin; DKFZp313L0718; GSN; GELS_HUMAN; Actin-depolymerizing factor.  
研究領(lǐng)域腫瘤  細胞生物  免疫學(xué)  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號2G6
交叉反應(yīng)Human, Mouse, 
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量80kDa
細胞定位細胞漿 分泌型蛋白 
性    狀Lyophilized or Liquid
濃    度1mg/ml
免 疫 原Recombinant human Gelsolin protein: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Gelsolin is a calcium dependent actin binding protein. It is a potent modulator of actin filament length and gelation. Gelsolin has been shown to exist in at least two variant forms, cytoplasmic gelsolin and plasma gelsolin. Plasma gelsolin has also been called actin depolymerizing factor (ADF) or brevin. Human plasma and rabbit macrophage gelsolins differ by the presence of a 25 amino acid residue extension at the NH2 terminus in the human plasma gelsolin, which appears to account for the difference in relative molecular weights.

Function:
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.

Subunit:
Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.

Subcellular Location:
Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted.

Tissue Specificity:
Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.

Post-translational modifications:
Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.

DISEASE:
Amyloidosis 5 (AMYL5) [MIM:105120]: A hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the villin/gelsolin family.
Contains 6 gelsolin-like repeats.

SWISS:
P06396

Gene ID:
2934

Database links:

Entrez Gene: 2934 Human

Entrez Gene: 227753 Mouse

Entrez Gene: 296654 Rat

Omim: 137350 Human

SwissProt: P06396 Human

SwissProt: P13020 Mouse

SwissProt: Q68FP1 Rat

Unigene: 522373 Human

Unigene: 21109 Mouse

Unigene: 103770 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.