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血管內(nèi)皮生長因子抗體
  • 產(chǎn)品貨號：
    BN42194R
  • 中文名稱：
    血管內(nèi)皮生長因子抗體
  • 英文名稱：
    Rabbit anti-VEGF Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN42194R-50ul

    50ul

    ￥1486.00

    交叉反應：Rabbit,Rat,Mouse,Human(predicted:Cow,Pig,Dog,Chicken) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN42194R-100ul

    100ul

    ￥2360.00

    交叉反應：Rabbit,Rat,Mouse,Human(predicted:Cow,Pig,Dog,Chicken) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN42194R-200ul

    200ul

    ￥3490.00

    交叉反應：Rabbit,Rat,Mouse,Human(predicted:Cow,Pig,Dog,Chicken) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱VEGF
中文名稱血管內(nèi)皮生長因子抗體
別    名Vascuoar endothelial growth factor A; VEGF A; vascular endothelial growth factor A isoform 2 precursor; Vegf; VEGFA; MGC70609; MVCD1; VEGF; VPF; VEGFA_HUMAN; Vascular endothelial growth factor A; VEGF-A; Vascular permeability factor; VPF; VEGF A Precursor.  



研究領域腫瘤  信號轉(zhuǎn)導  生長因子和激素  血管內(nèi)皮細胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat, Rabbit,  (predicted: Chicken, Dog, Pig, Cow, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
細胞定位細胞外基質(zhì) 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human VEGF:102-213/213 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.

Subunit:
Homodimer; disulfide-linked. Also found as heterodimer with PGF.

Subcellular Location:
Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.

Tissue Specificity:
Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed.

DISEASE:
Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

Similarity:
Belongs to the PDGF/VEGF growth factor family.

SWISS:
P15692

Gene ID:
7422

Database links:

Entrez Gene: 403802 Dog

Entrez Gene: 7422 Human

Entrez Gene: 22339 Mouse

Entrez Gene: 83785 Rat

Omim: 192240 Human

SwissProt: Q9MYV3 Dog

SwissProt: P15692 Human

SwissProt: Q00731 Mouse

SwissProt: P16612 Rat

Unigene: 73793 Human

Unigene: 282184 Mouse

Unigene: 1923 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

血管內(nèi)皮細胞生長因子(VEGF)是一種特異作用于血管內(nèi)皮細胞的多功能細胞因子，它能引起血管通透性增加，引起細胞外基質(zhì)成分改變,誘導血管形成.在炎癥、創(chuàng)傷愈合、心臟缺血、動脈粥樣硬化、糖尿病性視網(wǎng)膜病變及腫瘤形成等與血管生成和病變有關的諸多病理過程中起重要作用.
VEGF與血管生成有關，因而與腫瘤生長有很大關系，近年來受到很多關注。